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NSC 694623

CAS No. 907957-34-0

NSC 694623( —— )

Catalog No. M35440 CAS No. 907957-34-0

NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 of 15.9 μM against recombinant HAT p300/CBP-associated factor (PCAF) and exhibits anti-proliferative activity against certain cancer cells, making it useful for anti-cancer research.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NSC 694623
  • Note
    Research use only, not for human use.
  • Brief Description
    NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 of 15.9 μM against recombinant HAT p300/CBP-associated factor (PCAF) and exhibits anti-proliferative activity against certain cancer cells, making it useful for anti-cancer research.
  • Description
    NSC 694623 is a potent histone acetyltransferase (HAT) inhibitor with an IC50 value of 15.9 μM for recombinant HAT p300/CBP-associated factor (PCAF). NSC 694623 has antiproliferative activity against certain cancer cells. NSC 694623 can be used for researching anticancer.
  • In Vitro
    NSC 694623 has antiproliferative activity against SK-N-SH with an IC50 of 8.93 μM, and inhibits 21% of HCT116 at 25 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Histone Acetyltransferase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    907957-34-0
  • Formula Weight
    284.38
  • Molecular Formula
    C16H16N2OS
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (439.55 mM; Ultrasonic (<60°C)
  • SMILES
    O=C1N(SC=2C1=CC=CN2)C3=CC=C(CCCC)C=C3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Furdas SD, et al. Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89.?
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